Given that,

Correct Option

Based on the given information:

• A is the brother of B.
• E is the daughter of B.
• D is the brother of E.

From the last two statements, it is inferred that B is the parent of both D and E. Since A is the brother of B, A is the sibling of D's parent. Therefore, A is the uncle of D.

Incorrect Options

• Option 2 (B): B is the parent of D. A parent cannot be an uncle.
• Option 3 (C): C is the father of A. Since A is B's brother, C is also the father of B. As B is D's parent, C is the grandfather of D. A grandfather cannot be an uncle.
• Option 4 (E): E is the sister of D. A sibling cannot be an uncle.